منابع مشابه
Bypassing the requirement for MYC in lymphoma progression
tribute to pathologic thrombosis. It is generally accepted that the prothrombotic functions of VWF are directly related to multimer size. This and previous studies demonstrate that shear forces generated by flowing blood can cause the noncovalent but relatively stable assembly of very large VWF polymers from plasma multimers and, thus, enhance platelet adhesion and activation. The cleavage by A...
متن کاملBypassing the requirement for MYC in lymphoma progression
tribute to pathologic thrombosis. It is generally accepted that the prothrombotic functions of VWF are directly related to multimer size. This and previous studies demonstrate that shear forces generated by flowing blood can cause the noncovalent but relatively stable assembly of very large VWF polymers from plasma multimers and, thus, enhance platelet adhesion and activation. The cleavage by A...
متن کاملTargeted Deletion of Multiple CTCF-Binding Elements in the Human C-MYC Gene Reveals a Requirement for CTCF in C-MYC Expression
BACKGROUND Insulators and domain boundaries both shield genes from adjacent enhancers and inhibit intrusion of heterochromatin into transgenes. Previous studies examined the functional mechanism of the MYC insulator element MINE and its CTCF binding sites in the context of transgenes that were randomly inserted into the genome by transfection. However, the contribution of CTCF binding sites to ...
متن کاملComparison of the Initial Treatment Results of N-myc Positive and N-myc Negative Neuroblastoma Patients
Background: Neuroblastoma is the most common extra cranial malignant solid tumor of childhood. Various molecular and cytogenetic factors have been implicated in the pathogenesis of neuroblastoma, some of which have proven useful in predicting clinical behavior. Over expression of the oncogen N-myc, is an important indicator of prognosis. Materials and Methods: Our study was performed from 20...
متن کاملMYC Immunohistochemistry Predicts MYC Rearrangements by FISH
MYC is the proto-oncogene classically associated with Burkitt lymphoma (BL) located at chromosomal locus 8q24. Rearrangements of MYC are seen in nearly 100% of BL but have been reported in 3-16% of diffuse large B-cell lymphomas (DLBCLs). Rearrangements of MYC are tested for by flourescence in situ hybridization (FISH). In this study, we compared immunohistochemistry (IHC) using a monoclonal an...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2002
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20020708-01